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Watch Closely (one)pentobarbital will lessen the level or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the decrease in fentanyl plasma concentrations, not enough efficacy or, probably, progress of a wi